GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs3105593 | 1 | rs1395297 | chr15:50878509 | SPPL2A | chr15:50999739-51057910:- | -0.16 | -5.92 | 4.34E-9 | QT interval |
| BRCA | cis | rs4731120 | 1 | rs1395381 | chr7:123432100 | HYAL4 | chr7:123485223-123517529:+ | 0.21 | 3.44 | 0.000594 | Platelet count |
| BRCA | cis | rs1396626 | 1 | rs1396626 | chr1:96025546 | CNN3 | chr1:95362509-95392735:- | 0.13 | 3.77 | 0.000175 | Diabetic kidney disease |
| BRCA | cis | rs718314 | 1 | rs1398676 | chr12:26459420 | BHLHE41 | chr12:26272961-26278003:- | 0.13 | 3.42 | 0.000645 | Waist-hip ratio;Renal cell carcinoma |
| BRCA | cis | rs1401492 | 1 | rs1401492 | chr3:53680124 | ACTR8 | chr3:53901156-53916187:- | -0.31 | -4 | 6.87E-5 | Insulin resistance/response |
| BRCA | cis | rs1401492 | 1 | rs1401492 | chr3:53680124 | NEK4 | chr3:52744803-52804951:- | -0.21 | -3.47 | 0.000533 | Insulin resistance/response |
| BRCA | cis | rs1401492 | 1 | rs1401492 | chr3:53680124 | PBRM1 | chr3:52579368-52719866:- | -0.23 | -3.92 | 9.52E-5 | Insulin resistance/response |
| BRCA | cis | rs9309473 | 1 | rs1403284 | chr2:73726662 | ALMS1P | chr2:73872046-73912692:+ | -0.22 | -5.54 | 3.79E-8 | Metabolite levels |
| BRCA | cis | rs140330585 | 1 | rs140330585 | chr15:78866445 | AGPHD1 | chr15:78799906-78829714:+ | -0.15 | -3.41 | 0.000664 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio in COPD;Post bronchodilator FEV1/FVC ratio |
| BRCA | cis | rs140330585 | 1 | rs140330585 | chr15:78866445 | CHRNA5 | chr15:78857906-78886458:+ | -0.2 | -5.96 | 3.5E-9 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio in COPD;Post bronchodilator FEV1/FVC ratio |
| BRCA | cis | rs1322512 | 1 | rs1405694 | chr6:152946561 | VIP | chr6:153071933-153080898:+ | 0.12 | 4.1 | 4.5E-5 | Tonometry |
| BRCA | cis | rs6088813 | 1 | rs1406947 | chr20:33969530 | CPNE1 | chr20:34213968-34262539:- | 0.23 | 6.19 | 8.39E-10 | Height |
| BRCA | cis | rs6088813 | 1 | rs1406947 | chr20:33969530 | MMP24 | chr20:33814539-33864804:+ | 0.16 | 4.42 | 1.1E-5 | Height |
| BRCA | cis | rs6088813 | 1 | rs1406947 | chr20:33969530 | UQCC | chr20:33890383-33999833:- | 0.31 | 9.38 | 3.73E-20 | Height |
| BRCA | cis | rs9387478 | 1 | rs1407185 | chr6:117733650 | ROS1 | chr6:117609530-117747018:- | -0.14 | -4.84 | 1.45E-6 | Lung cancer |